CDI Faculty

David Lewis

David Lewis, M.D.

Dr. Lewis' research activities focus on the neural circuitry of the prefrontal cortex and related brain regions and the alterations of this circuitry in schizophrenia. The macaque monkey is a model experimental system for this circuitry, and postmortem human brain specimens are used to study the disease process. The goal of these studies is to define the pathogenetic mechanisms and pathophysiological processes that give rise to the cognitive deficits of schizophrenia and to identify potential targets for novel therapeutic interventions.

Positions

  • Chairman, Department of Psychiatry, University of Pittsburgh School of Medicine and Western Psychiatric Institute and Clinic
  • UPMC Professor in Translational Neuroscience, University of Pittsburgh School of Medicine and Western Psychiatric Institute and Clinic

 

Education

  • M.D., 1979, Ohio State University, Medicine

 

Relevant Publications

  • Arion D, Lewis DA. Altered expression of regulators of the cortical chloride transporters NKCC1 and KCC2 in schizophrenia. Arch Gen Psychiatry. 2011;68:21-31.
  • Volk DW, Eggan SM, Lewis DA. Alterations in metabotropic glutamate receptor 1α and regulator of G protein signaling 4 in the prefrontal cortex in schizophrenia. Am J Psychiatry. 2010;167:1489-1498.
  • Lewis DA, Sweet RA. Schizophrenia from a neural circuitry perspective: Advancing toward rational pharmacological therapies. J Clin Invest. 2009;119: 706-716.
  • Eggan SM, Hashimoto T, Lewis DA. Reduced cortical cannabinoid 1 receptor messenger RNA and protein expression in schizophrenia. Arch Gen Psychiatry. 2008;65:772-784.
  • Lewis DA, González-Burgos, G. Pathophysiologically-based treatment interventions in schizophrenia. Nature Medicine. 2006;12:1016-1022.