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CDI Faculty

Joshua Roffman, M.D., M.M.Sc. Dr. Roffman's work focuses on contributions of folate-related genes to negative symptoms, executive dysfunction, and related brain activation in schizophrenia. A CDI alumnus, Dr. Roffman is supported by two five-year career development awards, which include a K23 from NIMH and an Early Career Physician-Scientist Award from the Howard Hughes Medical Institute. He has also received career development awards from NARSAD (Young Investigator Award), the American Psychiatric Association (APIRE-Lilly Award) and the Charles King Postdoctoral Trust, as well as support from the NIH Loan Repayment Program. In addition, Dr. Roffman has served as director of the neuroscience curriculum for the MGH-McLean Psychiatry Residency Training Program, and has organized a research mentorship program for PGY1 residents.

Positions

• Assistant Professor, Department of Psychiatry, Harvard Medical School
  
  Assistant in Psychiatry, Department of Psychiatry, Massachusetts General Hospital
  
  Co-chair, Psychiatry Grand Rounds, Massachusetts General Hospital Psychiatry
  
  Director, Brain Genomics Research, Massachusetts General Hospital Psychiatry
  
  Deputy Editor, Harvard Review of Psychiatry
  
  

Education

• M.D., 2001, University of Maryland School of Medicine, Medicine
  
  M.M.Sc., 2010, Harvard Medical School, Clinical Investigation
  
  

Relevant Publications

• Roffman, J. L. (2011). Biomarkers and personalized psychiatry. Harvard Review of Psychiatry, 19, 99-101.
  
  
• Yeo, B. T., Krienen, F. M., Sepulcre, J., Sabuncu, M. R., Lashkari, D., Hollinshead, M., ... Buckner, R. L. (2011). The organization of the human cerebral cortex estimated by functional connectivity. Journal of Neurophysiology; in press.
  
  
• Roffman, J. L., Nitenson, A. Z., Agam, Y., Isom, M., Friedman, J. S., Dyckman, K. A., ... Manoach, D. S. (2011). A hypomethylating variant of MTHFR, 677C>T, blunts the neural response to errors in patients with schizophrenia and healthy individuals. PLoS One; in press.
  
  
• Roffman, J. L., Gollub, R. L., Calhoun, V. D., Wassink, T. H., Weiss, A. P., Ho, B. C., ... Manoach, D. S. (2008). MTHFR 677C>T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val>Met. Proceedings of the National Academy of Sciences of the USA, 105, 17573-17578.
  
  
• Roffman, J. L., Simon, A. B., Prasad, K. M., Truman, C. J., Morrison, J., Ernst, C. L. (2006). Neuroscience in psychiatry training: How much do residents need to know? American Journal of Psychiatry, 165, 911-918.
  

Funding for this conference was made possible (in part) by GRANT R25MH090947 from the National Institute of Mental Health (NIMH). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Mental Health or the National Institutes of Health.